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Figure 2 | Molecular Medicine

Figure 2

From: ERK-MAPK Signaling Opposes Rho-Kinase to Reduce Cardiomyocyte Apoptosis in Heart Ischemic Preconditioning

Figure 2

Representative photomicrographs of ventricular tissue stained for TUNEL for DNA breaks. A, I/R group; B, IPC group; C, IPC + PD98059 group; D, IPC + fasudil group; E, IPC + PD98059 + fasudil group; F, IPC + DMSO group. In the I/R group we observed a large number of TUNEL-positive cells. The percentage of TUNEL-positive cells of the IPC group was significantly reduced compared with the I/R group (*P < 0.05). After administration of PD98059, the percentage of TUNEL-positive cells was significantly increased (#P < 0.05 versus IPC group). And in the IPC + PD98059 + fasudil group, TUNEL-positive cells were significantly reduced (**P < 0.05 versus the IPC + PD98059 group).

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