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Figure 3 | Molecular Medicine

Figure 3

From: ERK-MAPK Signaling Opposes Rho-Kinase to Reduce Cardiomyocyte Apoptosis in Heart Ischemic Preconditioning

Figure 3

Western blot analysis of cleaved Caspase-3 in rat hearts of different groups (I/R, IPC, IPC + PD98059, IPC + fasudil, IPC + PD98059 + fasudil, IPC + DMSO). The amount of cleaved Caspase-3 attenuated in the IPC group (*P < 0.05 versus I/R). After administration of PD98059, the amount of cleaved Caspase-3 significantly increased (#P < 0.05 versus the IPC group). And in the IPC + PD98059 + fasudil group, the amount of cleaved Caspase-3 was significantly reduced (**P < 0.05 versus the IPC + PD98059 group).

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Molecular Medicine

ISSN: 1528-3658