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Figure 4 | Molecular Medicine

Figure 4

From: ERK-MAPK Signaling Opposes Rho-Kinase to Reduce Cardiomyocyte Apoptosis in Heart Ischemic Preconditioning

Figure 4

Changes in myocardial infarct size of the different groups (I/R, IPC, IPC + PD98059, IPC + fasudil, IPC + PD98059 + fasudil, IPC + DMSO) in rat hearts. The myocardial infarct sizes were similar between the IPC and IPC + DMSO groups. A significant reduction in myocardial infarct size was observed in the IPC (*P < 0.05 versus the I/R group). After administration of PD98059, the myocardial infarct size was increased (#P < 0.05 versus IPC group). And in the IPC + PD98059 + fasudil group, the infarct size was reduced (**P < 0.05 versus the IPC + PD98059 group).

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Molecular Medicine

ISSN: 1528-3658