Figure 3

The top-scoring network of interactions among the 3370 probe sets identified as significantly differentially expressed when we compared HCV with normal samples. The probe sets were subsequently analyzed by using the Ingenuity pathway analysis software (https://analysis.ingenuity.com). This software is designed to identify dynamically generated biological networks, global canonical pathways and global functions. At interconnections of significant functional networks, protein nodes appeared in different shades of red and green or white depending on being upregulated and downregulated or no-change, respectively, in HCV-cirrhotic samples.