Thrombin and Its Receptor Enhance ST-Segment Elevation in Acute Myocardial Infarction by Activating the KATP Channel

Table 1 EpiMAP₉₀ and EndoMAP₉₀ duration.

A. After TRAP and vehicle (TFA) perfusion to the left ventricular walls
	Before perfusion		10 min after perfusion		10 min after wash
	EpiMAP₉₀	EndoMAP₉₀	EpiMAP₉₀	EndoMAP₉₀	EpiMAP₉₀	EndoMAP₉₀
TRAP	153 ± 4	154 ± 2	135 ± 3^a#	156 ± 4	154 ± 2	159 ± 5
TFA	151 ± 2	152 ± 3	159 ± 2	156 ± 5	154 ± 4	153 ± 5
B. Before and after perfusion with HMR1098 + TRAP or 5-HD + TRAP
			5- HD		HMR1098
MAP₉₀			EpiMAP₉₀	EndoMAP₉₀	EpiMAP₉₀	EndoMAP₉₀
Perfusion of K-H solution			149 ± 2	152 ± 3	150 ± 2	151 ± 3
10 min after HMR1098/5HD + K-H solution perfusion			162 ± 3	164 ± 5	171 ± 4	173 ± 4
10 min after TRAP + HMR1098/5HD perfusion			152 ± 3^a,c	168 ± 3	165 ± 5	170 ± 3
5 min after washed by HMR1098/5HD
+ K-H solution perfusion			162 ± 4	165 ± 5	168 ± 2	171 ± 3
10 min after washed by K-H solution			151 ± 5	150 ± 1	156 ± 3	156 ± 4

Each value represents the mean ± SEM of five animals. P < 0.05 ^aEpiMAP₉₀ versus EndoMAP₉₀, ^bEpiMAP₉₀ in TRAP group versus EpiMAP₉₀ in TFA group, ^cEpiMAP₉₀ in 5HD + TRAP group versus EpiMAP₉₀ in HMR1098 + TRAP group.

ISSN: 1528-3658