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Table 2 Genotype and allele frequency of the CYP1A2*1F (A) allele in patients with PCT and controls in this study and in three previous studies.

From: CYP1A2*1F and GSTM1 Alleles Are Associated with Susceptibility to Porphyria Cutanea Tarda

   

Genotype frequency

Allele frequency

Study

PCT subtype

n

A/A, %

A/C, %

C/C, %

A, %

C, %

This study (USA)

1 & 2

66

55.1

39.1

5.8

75

25

 

1

50

60.0

36.0

4.0

78

22

 

2

16

31.0

56.0

13.0

59

41

 

Controls

72

36.1

51.4

12.5

62

38

Christiansen et al. (Denmark) (17)

1 & 2

53

71.7

22.6

5.7

83

17

 

1

40

70.0

27.5

2.5

84

16

 

2

13

76.5

7.7

15.4

81

19

 

Controls

60

46.7

43.3

10.0

68

32

Dereure et al. (France) (19)

1 & 2

49

38.8

53.1

6.1

67

33

 

1

45

N/A

N/A

N/A

N/A

N/A

 

2

4

N/A

N/A

N/A

N/A

N/A

 

Controls

48

39.6

47.9

12.5

64

37

Fontanella et al. (Spain) (18)

1 & 2

102

48.0

49.0

2.9

73

28

 

1

80

45.0

52.5

2.5

71

29

 

2

22

59.1

36.5

4.5

77

23

 

Controls

150

40.0

48.0

12.0

64

36

  1. aN/A, not available.