Table 2 Effect of gene deletion in acute lung injury.

Cytokines

TNF^−/−; TNF R1/R2^−/−

Ischemia/reperfusion-induced ALI

Not protective

(96)

IL-1β^+/+

Adenoviral gene transfer to transiently overexpress IL-1β in rat lungs after intratracheal administration induces acute lung injury

induce ALI

(214)

Chemokines and their receptors

CXCR2^−/−

LPS inhalation

Protective

(82)

CXCR2^−/−

Ischemia reperfusion

Protective

(81)

CXCR2^−/−

Ventilator-induced ALI in CXCR2^−/− mouse

Protective

(81)

IL-1β (Caspase

Bleomycin-induced lung injury

Protective

(97)

IL-18^−/−

Bleomycin-induced lung injury

Protective

(97)

CCR1^−/−

Pancreatitis-associated lung Injury

Protective

(215)

CXCL5^−/− (ENA-78)

Intratracheal application of E. coli

Protective

(86)

DARC^−/−

LPS inhalation

Not protective

(87)

Cell adhesion molecules

P-selectin^−/−

Cobra venom factor (CVF)-induced ALI

Not protective

(46)

ICAM-1^−/−

CVF-induced ALI;

Not protective

(46)

Granule proteins

Neutrophil elastase^−/−

Intraperitoneal infection with Gram-negative bacteria (Klebsiella pneumoniae and E. coli)

Not protective; increased mortality

(117)

Neutrophil elastase^−/−

Intratracheal application of LPS

Not protective, similar recruitment

(216)

Neutrophil elastase^−/− and Cathepsin G^−/−

Endotoxic shock with LPS

Decreased mortality and lung injury in comparison to wild type mice

(217)

MMP 8^−/−

Intratracheal application of LPS

Not protective, increased ALI

(153)

MMP 8^−/−

Ventilator-induced ALI (VILI)

Protective

(152)

MMP 9^−/−

Ozone-induced ALI

Not protective, increased ALI

(150)

MMP 9^−/−

Ventilator-induced ALI (VILI)

Not protective, increased ALI

(151)

α-Defensins^+/+ (transgenic mice)

Using mice transgenic for polymorphonuclear leukocyte expression of α-defensins; acid aspiration-induced ALI

Radical release

NADPH oxidase^−/−

Complement-induced ALI

not protected

(205)

NADPH oxidase 1^−/−NADPH oxidase 2^−/−

Hyperoxia-induced ALI

NADPH protective NADPH 2^−/− Not protective

(204)

Nitric oxide synthase^−/−

LPS-induced ALI

Protective

(207)