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Table 2. Frequency of high- and low-affinity DNA-reactive B cells in R4A-Tg mice treated with P, E2, or PPT.a

From: Differential Roles of Estrogen Receptors α and β in Control of B-Cell Maturation and Selection

 

P

E2

PPT

High-affinity

6/67 (9%)

15/65 (23.1%)b

14/70 (20%)b

Low-affinity

7/67 (10.5%)

5/65 (7.7%)

5/70 (7.1%)

  1. aThe Fisher exact test was performed to compare the frequency of high-and low-affinity DNA-reactive mature B cells in E2-treated or PPT-treated R4A-Tg WT mice, compared to P-treated mice.
  2. bP < 0.05 (P value signifies a difference compared to P-treated mice).
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Molecular Medicine

ISSN: 1528-3658