Figure 2
From: A Paradoxical Role for Myeloid-Derived Suppressor Cells in Sepsis and Trauma
Emergency myelopoiesis and the expansion of the MDSC population in sepsis. The figure demonstrates the changes in the early populations of HSCs and multipotent progenitors, which are the progenitors for MDSCs. Although expansion of the MDSC population can be explained in part through increased myelopoiesis, defects in the maturation and differentiation of these populations also contributes to their expansion and their immature phenotype.