A Paradoxical Role for Myeloid-Derived Suppressor Cells in Sepsis and Trauma

Table 1 Cell surface phenotyping of murine MDSC populations.^a

Study	Disease	MDSC classification	Additional markers used
Gabrilovich et al., J. Immunol. 2001 (57)	Cancer	Gr-1⁺, CD11b⁺	MHCII
Sinha et al., J. Immunol. 2005 (58)	Cancer	Gr-1⁺, CD11b⁺	MHC II, CD80/86, F4/80, CD11c,
Makarenkova et al., J. Immunol. 2006 (48)	Trauma	Gr-1⁺, CD11b⁺	MHC II, CD80/86, F4/80, CD11c, CD31
Delano et al., J. Exp. Med. 2007 (12)	Sepsis	Gr-1⁺, CD11b⁺	MHCII, CD31
Zhu et al., J. Immunol. 2007 (56)	Experimental autoimmune encephalomyelitis	Ly6C⁺, Ly6G⁺, Gr-1⁺, CD11b⁺	MHCII, CD80/86, F4/80, CD11c, CD31
Noel et al., Shock 2005 (31)	Burn	Gr-1⁺, CD11b⁺	F4/80, CD115, CD117
Youn et al., J. Immunol. 2008 (14)	Cancer	Ly6C⁺, Ly6G⁺, Gr-1⁺, CD11b⁺	CD80, CD115, CD124, PD-L1
Dolcetti et al., Eur. J. Immunol. 2010 (59)	Cancer	Ly6C⁺, Ly6G⁺, Gr-1⁺, CD11b⁺	F4/80, CD11c, CD31, CD124

^aAll investigators use both CD11b and GR-1 or Ly6C/Ly6G staining to characterize their MDSC population. However, it is evident that the populations may differ significantly in their expression of other cell surface markers.

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