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Figure 10 | Molecular Medicine

Figure 10

From: Selective Antihypertensive Dihydropyridines Lower Aβ Accumulation by Targeting both the Production and the Clearance of Aβ across the Blood-Brain Barrier

Figure 10

Effect of nilvadipine on cognitive behavior of Tg PS1 and Tg PS1/APPsw mice in the Morris water maze. (A) Learning curve for Morris water maze acquisition trials across a period of 9 d. (B) Learning curve for Morris water maze during the reversal period (hidden platform moved to a new location). (C) Effect of nilvadipine on memory retention in the Morris water maze (probe trials). Placebo-treated Tg PS1/APPsw mice have the worst learning performance in the Morris water maze compared with placebo-treated Tg PS1 littermate controls (P < 0.001) during the acquisition trials and the reversal. Nilvadipine treated Tg PS1/APPsw mice locate the hidden platform more efficiently than placebo-treated Tg PS1/APPsw mice (P < 0.04) during the acquisition trials and the reversal. Pooled probe trials for the Morris water maze show a significant increase in retention for Tg PS1 control littermates compared with Tg PS1/APPsw treated with the placebo (P < 0.01) as well as an improved memory retention for nilvadipine-treated Tg PS1/APPsw mice compared with placebo treated Tg PS1/APPsw (P < 0.02).

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Molecular Medicine

ISSN: 1528-3658