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Figure 4 | Molecular Medicine

Figure 4

From: Selective Antihypertensive Dihydropyridines Lower Aβ Accumulation by Targeting both the Production and the Clearance of Aβ across the Blood-Brain Barrier

Figure 4

Effect of antihypertensive DHPs on Aβ production in neuroblastoma SHSY cells overexpressing the C99 C-terminal fragment of APP. C99 overexpressing SHSY cells were treated for 24 h with different DHPs. Results were expressed as a percentage of the Aβ1−40 values observed in the vehicle treatment conditions ± S.E.M. ANOVA reveals no statistically significant main effect for the different doses of the DHPs tested on Aβ1−40 production (P > 0.05) showing that antihypertensive DHPs do not inhibit the production of Aβ1−40 by C99-overexpressing cells. (Average Aβ1−40 values observed in the control conditions were 770.1 pg/mL.)

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Molecular Medicine

ISSN: 1528-3658