Figure 2

GNMT expression significantly alters hepatic folate status in (A) GNMT transgenic mice (GNMT^tg) (n = 6), compared with the wild-type (WT) littermates (n = 6); and in (B) the GNMT knockout mice (GNMT^nul homozygous mice n = 5), compared with age matched littermates. GNMT^wt: wild-type (n = 8); GNMT^het: heterozygous (n = 7). (C) Liver folate concentrations were positively correlated with the liver GNMT expression levels when both models were combined (r = 0.53, P = 0.002, n = 32).