Table 2 Some examples of cellular crosstalk allowing NK cell response during bacterial infections or PAMP challenge.
From: Natural Killer (NK) Cells in Antibacterial Innate Immunity: Angels or Devils?
Cellular crosstalk with NK cells and type of infection or activation | NK cell functions | References |
|---|---|---|
Dentritic cells | Â | Â |
LPS | Proliferation, cytotoxicity, IFN-γ production | Goodier et al. J. Immunol. 2000, 165, 139a |
LPS or M, tuberculosis | CD69 expression, IFN-γ production | Gerosa et al. J. Exp. Med. 2002, 195, 327 |
TLR3, -4, -7 and -9 agonists | IFN-γ production and cytotoxicity | Lucas et al. Immunity. 2007, 26, 503 |
L. monocytogenes | IFN-γ production | Lucas et al. Immunity. 2007, 26, 503; Kang et al. Immunity. 2008, 29, 819; Humann and Lenz. J. Immunol. 2010, 184, 5172 |
Pam2Cys lipopeptides | CD69 expression, cytotoxicity and IFN-γ production | Azuma et al. PLoS One. 2010, 5, e12550 |
Chlamydia muridarum Monocytes/macrophages | IFN-γ production | Jiao et al. J. Immunol. 2011, 187, 401 |
CpG DNA | IFN-γ production | Chace et al. Clin. Immun. Immunopathol. 1997, 84, 185 |
Legionella pneumophila | IFN-γ production and cytotoxicity | Blanchard et al. Infect. Immun., 1988, 56, 1187 |
L. monocytogenes | IFN-γ production | Wherry et al. Infect. Immun. 1991, 59, 1709; Tripp et al. PNAS. 1993, 90, 3725 |
P. aeruginosa exotoxin A | IFN-γ production and cytotoxicity | Michalkiewicz et al., Immunol. Lett. 1999, 69, 359 |
S. aureus; L. johnsonii | CD69 expression, IFN-γ production | Haller et al. Clin. Diag. Lab. Immun. 2002, 9, 649 |
LPS | CD69 expression | Scott et al. Clin. Exp. Immunol. 2004, 137, 469 |
TLR2, -3 and -4 agonists | IFN-γ production | Tu et al. J. Exp. Med. 2008, 205, 233 |
Salmonella | CD69 expression, cytotoxicity and IFN-γ | Lapaque et al. J. Immunol. 2009, 182, 4339 |
Kupffer cells | Â | Â |
TLR2, -3 and -4 agonists | IFN-γ production | Tu et al. J. Exp. Med. 2008, 205, 233 |
Poly I:C + D-GalN in vivo | IFN-γ production | Hou et al. Hepatology. 2009, 49, 940 |
Neutrophils | Â | Â |
Legionella | IFN-γ production | Sporri et al., J. Immunol. 2008, 181, 7121 |
LPS + IL-2 or IL-15/IL-18 | IFN-γ production | Costantini et al. Blood. 2011, 117, 1677 |
T-lymphocytes | Â | Â |
Staphylococcal enterotoxin B-activated T cells | IFN-γ production and cytotoxicity | D’Orazio et al. J. Immunol. 1995, 154, 1014 |
LPS-treated γδ T cells | IFN-γ production | Andrews et al. Immunol. Cell. Biol. 2011, 89, 739 |
B-lymphocytes | Â | Â |
L. monocytogenes | IFN-γ production | Bao et al. Eur. J. Immunol. 2011, 41, 657 |
Mast cells | Â | Â |
LPS, Poly(I:C), CpG | IFN-γ production | Vosskuhl et al. J. Immunol. 2010, 119, 25 |
Epithelial cells | Â | Â |
Chlamydia trachomatis | IFN-γ production | Hook et al. FEMS Immunol. Med. Microb. 2005, 45, 113 |