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Figure 4 | Molecular Medicine

Figure 4

From: Local Fetal Lung Renin-Angiotensin System as a Target to Treat Congenital Diaphragmatic Hernia

Figure 4

In vivo antenatal PD-123319 treatment effects on lung growth. (A) Ratio of left, right and total lung-to-body weight in control (C), nitrofen (N) and CDH groups treated with saline (C + S, N + S, CDH + S) or PD-123319 (C + PD, N + PD, CDH + PD). Antenatal administration of PD-123319 enhanced lung growth in all studied groups. (B) Effect of PD-123319 treatment on left, right and total lung hypoplasia. Prenatal administration of PD-123319 ameliorated both left and right lung hypoplasia. Results are expressed as %. P < 0.001: *versus C + S, †versus N + S, ‡versus CDH + S, ‖versus C + PD, §versus N + PD. For left lung, there is a statistically significant interaction between variables: disease-treatment (P = 0.009).

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