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Table 1 ABR thresholds and latencies.

From: Insulin Receptor Substrate 2 (IRS2)-Deficient Mice Show Sensorineural Hearing Loss That Is Delayed by Concomitant Protein Tyrosine Phosphatase 1B (PTP1B) Loss of Function

 

Genotype

 

Age 3–5 wks

Age 8–16 wks

 

Irs2 +/+ Ptpn1 +/+

Irs2 −/− Ptpn1 +/+

Ptpn1 −/− Irs2 +/+

Irs2 −/− Ptpn1 −/−

Irs2 +/+ Ptpn1 +/+

Irs2 −/− Ptpn1 +/+

Ptpn1 −/− Irs2 +/+

Irs2 −/− Ptpn1 −/−

n

9

7

10

6

8

18

9

8

ABR threshold (dB SPL)

        

Click

39 ± 3

80 ± 10a

36 ± 4

38 ± 3

36 ± 4

79 ± 8a

38 ± 4

69 ± 10a

8 kHz

39 ± 5

73 ± 6a

42 ± 4

42 ± 4

39 ± 6

81 ± 8a

43 ± 5

69 ± 17a

16 kHz

37 ± 7

67 ± 6a

35 ± 12

35 ± 3

35 ± 5

72 ± 10a

37 ± 5

67 ± 12a

20 kHz

39 ± 7

80 ± 10a

41 ± 8

40 ± 8

39 ± 7

82 ± 11a

40 ± 6

71 ± 15a

40 kHz

49 ± 4

90 ± 10a

48 ± 6

50 ± 7

43 ± 5

90 ± 7a

47 ± 8

77 ± 16a

n

9

6

9

6

8

18

9

8

Peak latency (ms)

        

I

1.28 ± 0.08

1.39 ± 0.14a

1.35 ± 0.0

1.32 ± 0.06

1.28 ± 0.09

1.32 ± 0.08c

1.30 ± 0.10

1.26 ± 0.09

II

2.16 ± 0.09

2.30 ± 0.13b

2.36 ± 0.07c

2.28 ± 0.05

2.20 ± 0.12

2.17 ± 0.12

2.12 ± 0.10c

2.16 ± 0.04

IV

3.88 ± 0.12

4.14 ± 0.90a

4.48 ± 0.20

4.22 ± 0.09a

3.85 ± 0.15

3.93 ± 0.14

3.83 ± 0.14

3.96 ± 0.15

Interpeak latency (ms)

        

I–II

0.87 ± 0.10

0.90 ± 0.05

1.01 ± 0.07c

0.95 ± 0.04b

0.92 ± 0.10

0.84 ± 0.09c

0.82 ± 0.11c

0.90 ± 0.08

II–IV

1.72 ± 0.13

1.84 ± 0.09c

2.12 ± 0.16

1.94 ± 0.06a

1.65 ± 0.14

1.76 ± 0.09c

1.71 ± 0.08

1.79 ± 0.11c

I–IV

2.59 ± 0.09

2.75 ± 0.12c

3.13 ± 0.21

2.89 ± 0.06a

2.57 ± 0.10

2.60 ± 0.13

2.53 ± 0.15

2.69 ± 0.15

  1. ABR thresholds (mean ± SD in dB SPL) in response to click and tone burst (4–40 kHz) stimuli were determined in young (3- to 5-wk-old) and adult (8- to 16-wk-old) mice from the four genotypes analyzed. Click ABR peak and interpeak latencies (mean ± SD, in ms) are shown in the four genotypes studied at the two ages analyzed. Statistically significant differences were found when comparing mutant mice with wild-type mice:
  2. aP < 0.001.
  3. bP < 0.05.
  4. cP < 0.01.