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Figure 1 | Molecular Medicine

Figure 1

From: Constitutive Overexpression of the Oncogene Racl in the Airway of Recurrent Respiratory Papillomatosis Patients Is a Targetable Host-Susceptibility Factor

Figure 1

Rac1 is overexpressed in clinically normal airway tissues of RRP patients. (A) A representative Western blot, showing EGFR and Rac1 expression levels in normal laryngeal tissue from a non-RRP patient (N), compared with papilloma tissue (P) and autologous clinically normal laryngeal tissue (CNL) and clinically normal tracheal tissue (CNT) from an RRP patient. Actin is shown as a loading control. The graph shows mean ± SD of Rac1 levels of papillomas and clinically normal larynx and tracheal biopsies from six different patients compared with biopsies from a non-RRP patient. A previous publication showed the statistical difference between normal (N) and papilloma (P) tissues (4). There was no statistically significant difference in Rac1 expression between the three tissue types from RRP patients. (B) Immunohistochemical expression pattern of Rac1 in papillomas and clinically normal laryngeal and tracheal tissues of RRP patients, representative of staining patterns seen in one patient included in Figure 1A and five additional patients.

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Molecular Medicine

ISSN: 1528-3658