| Anti-FXa activity, %b | |
---|
| 37°C | 42°C | Activity reduction, %c |
---|
Control | 100.0 ± 5.1 | 73.5 ± 3.7 | 26.5 |
A393 | 47.8 ± 2.3 | 28.4 ± 2.2 | 40.6 |
R393H | 54.8 ± 1.8 | 21.3 ± 3.5 | 61.1 |
R393C | 50.5 ± 1.1 | 25.3 ± 4.1 | 49.9 |
- aData are mean ± SD of three independent measurements.
- bPercentage of the activity observed in a pool of 100 healthy subjects.
- cReduction of activity induced by heating at 42°C and considering the value observed at 37°C for control plasma as 100%.