Skip to main content
Figure 2 | Molecular Medicine

Figure 2

From: Female Mice Are More Susceptible to Nonalcoholic Fatty Liver Disease: Sex-Specific Regulation of the Hepatic AMP-Activated Protein Kinase-Plasminogen Activator Inhibitor 1 Cascade, but Not the Hepatic Endotoxin Response

Figure 2

Sex differences in portal endotoxin levels, protein concentration of MyD88 and mPGES1 and -2 mRNA expression levels in livers of mice with steatosis induced by feeding a 30% fructose solution. (A) Portal endotoxin levels and (B,C) representative photomicrographs of MyD88 protein staining (630x with oil immersion) as well as densitometric analysis of staining. Expression of (D) mPGES1 and (E) mPGES2 mRNA in livers of male and female mice. Expression of mRNA was determined by real time RT-PCR with Ī²-actin as a reference gene in the liver. Data are shown as means Ā± SEM (n = 6) and are specified as -fold induction. Cā€”water (control); Fā€”30% fructose solution; *p < 0.05 compared with respective water-fed control mice; **p < 0.01 compared with respective water-fed control mice.

Back to article page

Molecular Medicine

ISSN: 1528-3658