Figure 1From: Peptide Mimetic of the S100A4 Protein Modulates Peripheral Nerve Regeneration and Attenuates the Progression of Neuropathy in Myelin Protein P0 Null MicePeptide mimetics of S100A4 affect recovery after sciatic nerve crush in rats. (A) Neuritogenic motifs of S100A4 (H3 and H6) mapped on the three-dimensional structure of the protein (PDB: 1M31). (B, C) H3, but not H6, promotes restoration of an SFI after crush injury (B) and increases the number of S100-positive fibers in the regenerated sciatic nerve at 3 wks after crush (C). *p <: 0.05 versus vehicle (Veh), one-way ANOVA. (A-E) Veh, H3 and H6 indicate the lesioned side of the vehicle-, H3-, and H6-treated groups, respectively. (D) S100A4 mimetics promote restoration of a sensory function after crush injury, as assessed by the pinprick test. A pinprick score was assigned from no response (0), reduced or inconsistent responses (1), to normal reaction (2). (E) S100A4 mimetics increase sensory reinnervation after crush injury to >50% of intact (unlesioned side of the vehicle-treated group). Left, fluorescent micrographs of regenerated sensory terminals in the plantar paw skin 21 d after crush, anti-PGP 9.5 immunostaining. Scale bar = 100 µm. Epi, epidermis; Der, dermis. Right, quantification of sensory innervation in the epidermis, *p <: 0.05 versus Veh, one-way ANOVA. (A-E) Number of animals, n = 9/10/10 (Veh/H3/H6).Back to article page