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Figure 5 | Molecular Medicine

Figure 5

From: High Mobility Group Box 1 Contributes to the Pathogenesis of Experimental Pulmonary Hypertension via Activation of Toll-like Receptor 4

Figure 5

HMGB1 promotes endothelial dysfunction and inflammation in hypoxia-induced PH. (A) Plasma ET-1 in WT mice treated with aHMGB1 antibody or control IgG (50 µg every other day, IP) during hypoxia (n = 6 per group). (B) ICAM levels of lung homogenate from WT mice treated with αHMGB1 antibody or control IgG (50 µg every other day, IP) during hypoxia (n = 6 per group). Untreated normoxic and hypoxic WT mice served as controls (A and B). Data represent the mean ± SEM of six mice per group. Analysis of variance: *P < 0.05.

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Molecular Medicine

ISSN: 1528-3658