Upregulation of SPRR3 Promotes Colorectal Tumorigenesis

Table 2 SPRR3 expression associated with demographic and biological parameters in 128 sporadic colorectal cancers

	Percentage of patients with SPRR3 expression^a
Parameters	Positive expression	P value^b	Overexpression	P value^b
Sex, male/female	59.4/75	0.045^c	25/39.1	0.065
Age, years, ≤50/>50	73.3/65.3	0.279	30/32.7	0.486
Stage,^d I + II/III + IV	66/68	0.482	26.4/36	0.171
Tumor characteristics
Site, right colon/left colon^e	76/65	0.211	40/30.1	0.235
Growth pattern, expanding/infiltrative	67.9/63.2	0.436	33.9/21.1	0.201
Differentiation, well and moderately differentiated/poorly differentiated and mucinous	67/69.2	0.569	29.6/53.8	0.075
Lymphovascular invasion, no/yes	55.2/80.3	0.002^c	20.9/44.3	0.004^c
Either MLH1 or MSH2 expression, no/yes	77.8/70.2	0.484	66.7/32.1	0.048^c

^aCategory I includes 2 grades, negative at ≤10% and positive at >10% staining cells, and category II includes 2 grades, downregulation at ≤50% and overexpression at >50% staining cells, respectively.
^bCross-table analysis using Fisher exact test.
^cP > 0.05.
^dCancer staging according to the American Joint Committee on Cancer (sixth edition, 2001).
^eRight colon, cecum-splenic flexure of the transverse colon; left colon, descending colon-the rectum.

ISSN: 1528-3658