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  1. Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide but has no effective treatment. Amyloid beta (Aβ) protein, a primary risk factor for AD, accumulates and aggregates in the brain ...

    Authors: Yuki Kawaguchi, Junpei Matsubayashi, Yutaka Kawakami, Ryohei Nishida, Yuji Kurihara and Kohtaro Takei
    Citation: Molecular Medicine 2022 28:154
    Content type: Research article Published on:

  3. Autoinflammatory diseases, a diverse group of inherited conditions characterized by excessive innate immune activation, have limited therapeutic options. Neuroimmune circuits of the inflammatory reflex control...

    Authors: Ibrahim T. Mughrabi, Mahendar Ochani, Mirza Tanovic, Ping Wang, Betty Diamond, Barbara Sherry, Valentin A. Pavlov, Seza Ozen, Daniel L. Kastner, Jae Jin Chae and Yousef Al-Abed
    Citation: Molecular Medicine 2022 28:148
    Content type: Short report Published on:

  4. Deregulated autophagy in diabetes has been a field of many experimental studies recently. Impaired autophagy in diabetic kidneys orchestrates every step of diabetic nephropathy (DN) pathogenesis. This study ai...

    Authors: Mona M. Watany, Hemat E. El-Horany, Marwa M. Elhosary and Ahmed A. Elhadidy
    Citation: Molecular Medicine 2022 28:147
    Content type: Research article Published on:

  5. The low efficiency of treatment strategies is one of the main obstacles to developing cancer inhibitors. Up to now, various classes of therapeutics have been developed to inhibit cancer progression. Peptides d...

    Authors: Mohammad Mahmoudi Gomari, Shadi Abkhiz, Taha Ghantab Pour, Ehsan Lotfi, Neda Rostami, Fatemeh Nafe Monfared, Babak Ghobari, Mona Mosavi, Behruz Alipour and Nikolay V. Dokholyan
    Citation: Molecular Medicine 2022 28:146
    Content type: Review Published on:

  6. Since angiogenesis occurs as the pathological process following myocardial infarction to alleviate ischemia, therapeutic angiogenesis has been proposed to be a cardioprotective strategy. CD44 has been implicat...

    Authors: Qing Zhang, Li Chen, Liyi Huang, Hongxin Cheng, Lu Wang, Lin Xu, Danrong Hu, Chengqi He, Chenying Fu and Quan Wei
    Citation: Molecular Medicine 2022 28:145
    Content type: Research article Published on:

  8. Mesenchymal stem cells (MSCs) are multipotent stromal cells and could exert hepatoprotective effects against acute liver injury, steatohepatitis, and fibrogenesis. Here, we evaluated the effects of human adipo...

    Authors: Masateru Nomura, Joseph George, Chieko Hashizume, Takashi Saito, Yoshimichi Ueda, Yasuhito Ishigaki, Mutsumi Tsuchishima and Mikihiro Tsutsumi
    Citation: Molecular Medicine 2022 28:143
    Content type: Research article Published on:

  9. Activated microglia play a key role in initiating the inflammatory cascade following ischemic stroke and exert proinflammatory or anti-inflammatory effects, depending on whether they are polarized toward the M...

    Authors: Zining Yu, Guangjun Su, Limei Zhang, Gaigai Liu, Yonggang Zhou, Shicai Fang, Qian Zhang, Tianyun Wang, Cheng Huang, Zhihua Huang and Liangdong Li
    Citation: Molecular Medicine 2022 28:142
    Content type: Research article Published on:

  10. Tetrandrine, a bisbenzylisoquinoline (BBI) alkaloid extracted from Stephania tetrandra (S. Moore), and is widely used in several diseases such as tuberculosis, hyperglycemia, malaria, and tumors. Tetrandrine was ...

    Authors: Jiarui Li, Xiang Li, Shengji Zhou, Yuxin Wang, Yang Lu, Quan Wang and Fengchao Zhao
    Citation: Molecular Medicine 2022 28:141
    Content type: Research article Published on:

  11. Analyzing disease–disease relationships plays an important role for understanding etiology, disease classification, and drug repositioning. However, as cardiovascular diseases with causative links, the molecul...

    Authors: Lin Chen, Ya-Nan Yu, Jun Liu, Yin-ying Chen, Bo Wang, Yi-Fei Qi, Shuang Guan, Xi Liu, Bing Li, Ying-Ying Zhang, Yuanhui Hu and Zhong Wang
    Citation: Molecular Medicine 2022 28:140
    Content type: Research article Published on:

  12. Neuroinflammation is a major mechanism in neurodegenerative diseases such as Alzheimer’s disease (AD), which is a major healthcare problem. Notwithstanding of ample researches figured out possible molecular me...

    Authors: Esraa M. Mosalam, Aya Ibrahim Elberri, Amany Said Sallam, Heba Rady Salem, Ebtehal M. Metwally, Mahmoud S. Abdallah, Moataz A. Shaldam and Hend E. Abo Mansour
    Citation: Molecular Medicine 2022 28:139
    Content type: Research article Published on:

  13. The long chain non-coding RNA HOXA11-OS was recently identified. Increasing studies have shown that HOXA11-OS has regulatory effects on genes in gastric cancer, prostate cancer, and various kidney diseases, bu...

    Authors: Xiuhong Pan, Shanshan Chen, Ruiwen Shen, Sen Liu and Yanwu You
    Citation: Molecular Medicine 2022 28:138
    Content type: Research article Published on:

  14. Intestinal barrier dysfunction, which is associated with reactive enteric glia cells (EGCs), is not only a result of early sepsis but also a cause of multiple organ dysfunction syndrome. Inhibition of platelet...

    Authors: Bo Cheng, Mengyu Du, Shuxuan He, Lan Yang, Xi Wang, Hui Gao, Haiqing Chang, Wei Gao, Yan Li, Qiang Wang and Yansong Li
    Citation: Molecular Medicine 2022 28:137
    Content type: Research article Published on:

  15. A chronic inflammatory disease caused by disturbances in metabolism, diabetic nephropathy (DN) is a chronic inflammatory disease. Pyroptosis is a novel form of programmed cell death in many inflammation-relate...

    Authors: ChangYan Li, JingYuan Ma, Niroj Mali, Le Zhang, Tao Wei, LuYao Shi, Fang Liu, Fan WenXing and Jing Yang
    Citation: Molecular Medicine 2022 28:136
    Content type: Research article Published on:

  16. Rheumatoid arthritis (RA) is a complex autoimmune disease with multiple etiological factors, among which aberrant memory CD4 T cells activation plays a key role in the initiation and perpetuation of the diseas...

    Authors: Xiu Teng, Da-Chao Mou, Hui-Fang Li, Ling Jiao, Sha-Sha Wu, Jin-Kui Pi, Yan Wang, Meng-Li Zhu, Meng Tang and Yi Liu
    Citation: Molecular Medicine 2022 28:135
    Content type: Research article Published on:

  17. Circular RNA (circ) AFF4 was documented to regulate osteogenesis but the underlying mechanism remains to be elucidated. The preliminary study showed that circ_AFF4 may promote osteogenesis via FNDC5/Irisin. Fu...

    Authors: Ansong Liu, Yong Chen, Da Zhong, Chenggong Wang, Mi Yu, Chao Liu, Zhijun Yang, Wenkang Chen and Ke Yin
    Citation: Molecular Medicine 2022 28:134
    Content type: Research article Published on:

  18. This study probes into the function and mechanism of bone marrow mesenchymal stem cell (BMSC)-derived exosomes loaded with miR-150-5p in mechanical allodynia.

    Authors: Shuangqing Li, Ciying Huang, Chao Tu, Ruiqi Chen, Xiaolei Ren, Lin Qi and Zhihong Li
    Citation: Molecular Medicine 2022 28:133
    Content type: Research article Published on:

  19. Cancer is a leading disease-related cause of death worldwide. Despite advances in therapeutic interventions, cancer remains a major global public health problem. Cancer pathogenesis is extremely intricate and ...

    Authors: Ying Liu, Xiaoge Li, Xuehao Zhou, Jianxun Wang and Xiang Ao
    Citation: Molecular Medicine 2022 28:132
    Content type: Review Published on:

  20. Respiratory failure in severe coronavirus disease 2019 (COVID-19) is associated with a severe inflammatory response. Acetylcholine (ACh) reduces systemic inflammation in experimental bacterial and viral infect...

    Authors: Sergio Fragoso-Saavedra, Isaac Núñez, Belem M. Audelo-Cruz, Sarahi Arias-Martínez, Daniel Manzur-Sandoval, Alejandro Quintero-Villegas, H. Benjamín García-González, Sergio L. Carbajal-Morelos, Sergio PoncedeLeón-Rosales, José Gotés-Palazuelos, José A. Maza-Larrea, J. Javier Rosales-de la Rosa, Dafne Diaz-Rivera, Edgar Luna-García, Elvira Piten-Isidro, Perla M. Del Río-Estrada…
    Citation: Molecular Medicine 2022 28:131
    Content type: Research article Published on:

  21. Obesity is one of the major public health problems threatening the world, as well as a potential risk factor for chronic metabolic diseases. There is growing evidence that iron metabolism is altered in obese p...

    Authors: Fangyi Qiu, Lei Wu, Guang Yang, Cong Zhang, Xiaofang Liu, Xiance Sun, Xin Chen and Ningning Wang
    Citation: Molecular Medicine 2022 28:130
    Content type: Review Published on:

  22. Curcumin is a polyphenolic compound derived from turmeric that has potential beneficial properties for cardiovascular and renal diseases and is relatively safe and inexpensive. However, the application of curc...

    Authors: Mitko Mladenov, Jane Bogdanov, Bogdan Bogdanov, Nikola Hadzi-Petrushev, Andre Kamkin, Radoslav Stojchevski and Dimiter Avtanski
    Citation: Molecular Medicine 2022 28:129
    Content type: Review Published on:

  24. Intestinal barrier dysfunction, which is associated with reactive enteric glia cells (EGCs), is not only a result of early sepsis but also a cause of multiple organ dysfunction syndrome. Inhibition of platelet...

    Authors: Bo Cheng, Mengyu Du, Shuxuan He, Lan Yang, Xi Wang, Hui Gao, Haiqing Chang, Wei Gao, Yan Li, Qiang Wang and Yansong Li
    Citation: Molecular Medicine 2022 28:127
    Content type: Research article Published on:

    The Correction to this article has been published in Molecular Medicine 2022 28:149

  25. Pyroptosis is a form of programmed cell death involved in the pathophysiological progression of hypoxic pulmonary hypertension (HPH). Emerging evidence suggests that N6-methyladenosine (m6A)-modified transcrip...

    Authors: Xiaoying Wang, Qian Li, Siyu He, June Bai, Cui Ma, Lixin Zhang, Xiaoyu Guan, Hao Yuan, Yiying Li, Xiangrui Zhu, Jian Mei, Feng Gao and Daling Zhu
    Citation: Molecular Medicine 2022 28:126
    Content type: Research article Published on:

  26. Oxidative stress-caused damage to the retinal pigment epithelium (RPE) underlies the onset and progression of age-related macular degeneration (AMD). Impaired mitochondrial biogenesis sensitizes RPE cells to m...

    Authors: Xiaonan Zhuang, Jun Ma, Gezhi Xu and Zhongcui Sun
    Citation: Molecular Medicine 2022 28:125
    Content type: Research article Published on:

  27. Uncoupling protein 2 (UCP2), activated by excessive reactive oxygen species (ROS) in vivo, has the dual effect of reducing ROS to protect against oxidative stress and reducing ATP production to regulate cellul...

    Authors: Chunli Zhao, Zijing Yang, Zhongrui Chen, Wenqi Liang, Shusheng Gong and Zhengde Du
    Citation: Molecular Medicine 2022 28:124
    Content type: Research article Published on:

  28. Our previous data demonstrated that miR-19b expression was increased in human lung microvascular endothelial cells in-vitro-, in-vivo and in patients with hemorrhagic shock, leading to a decrease in syndecan-1 mR...

    Authors: Feng Wu, Jian-Ying Wang, Brooke Dorman, Ahmad Zeineddin and Rosemary Ann Kozar
    Citation: Molecular Medicine 2022 28:123
    Content type: Research article Published on:

  29. Long-COVID is characterized by prolonged, diffuse symptoms months after acute COVID-19. Accurate diagnosis and targeted therapies for Long-COVID are lacking. We investigated vascular transformation biomarkers ...

    Authors: Maitray A. Patel, Michael J. Knauer, Michael Nicholson, Mark Daley, Logan R. Van Nynatten, Claudio Martin, Eric K. Patterson, Gediminas Cepinskas, Shannon L. Seney, Verena Dobretzberger, Markus Miholits, Brian Webb and Douglas D. Fraser
    Citation: Molecular Medicine 2022 28:122
    Content type: Research article Published on:

  30. Stent implantation-induced neointima formation is a dominant culprit in coronary artery disease treatment failure after percutaneous coronary intervention. Ferroptosis, an iron-dependent regulated cell death, ...

    Authors: Shunchi Zhang, Yanrou Bei, Yueling Huang, Yimin Huang, Lianjie Hou, Xi-Long Zheng, Yiming Xu, Shaoguo Wu and Xiaoyan Dai
    Citation: Molecular Medicine 2022 28:121
    Content type: Research article Published on:

  31. The miR-351 gene is significantly upregulated in diabetic mice with atherosclerosis. However, the mechanism by which its presence is important for the overall disease has not been elucidated. Therefore, this s...

    Authors: Hong Li, Dan Song, Qihui Liu, Linlin Li, Xiaoshi Sun, Jiamei Guo, Dianlian Li and Ping Li
    Citation: Molecular Medicine 2022 28:120
    Content type: Research article Published on:

  33. Spinal cord injury (SCI) is a devastating neurological state causing physical disability, psychological stress and financial burden. SCI global rate is estimated between 250,000 and 500,000 individuals every y...

    Authors: Amir Mohammad Malvandi, Seyed Hamidreza Rastegar-moghaddam, Saeede Ebrahimzadeh-Bideskan, Giovanni Lombardi, Alireza Ebrahimzadeh-Bideskan and Abbas Mohammadipour
    Citation: Molecular Medicine 2022 28:118
    Content type: Review Published on:

  34. Lipid accumulation in tubular cells plays a key role in diabetic kidney disease (DKD). Targeting lipid metabolism disorders has clinical value in delaying the progression of DKD, but the precise mechanism by w...

    Authors: Chanyue Zhao, Li Li, Chenrui Li, Chengyuan Tang, Juan Cai, Yu Liu, Jinfei Yang, Yiyun Xi, Ming Yang, Na Jiang, Yachun Han, Yan Liu, Shilu Luo, Li Xiao and Lin Sun
    Citation: Molecular Medicine 2022 28:117
    Content type: Research article Published on:

  35. Cataracts are the leading cause of blindness and a common ocular complication of diabetes. The epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs) and altered autophagic activity occur duri...

    Authors: Jiyuan Ma, Wei Ye, Yunshu Yang, Tong Wu, Yafen Wang, Ji Li, Rui Pei, Mengmei He, Luning Zhang and Jian Zhou
    Citation: Molecular Medicine 2022 28:116
    Content type: Research article Published on:

  36. O-linked β-d-N-acetylglucosamine (O-GlcNAc) is an important post-translational modification of serine or threonine residues on thousands of proteins in the nucleus and cytoplasm of all animals and plants. In euka...

    Authors: Qingsong Lu, Xiaozhen Zhang, Tingbo Liang and Xueli Bai
    Citation: Molecular Medicine 2022 28:115
    Content type: Review Published on:

  37. Immunoglobulin G (IgG) N-glycans have been shown to be associated with the risk of type 2 diabetes (T2D) and its risk factors. However, whether these associations reflect causal effects remain unclear. Further...

    Authors: Biyan Wang, Di Liu, Manshu Song, Wei Wang, Bo Guo and Youxin Wang
    Citation: Molecular Medicine 2022 28:114
    Content type: Research article Published on:

  38. HNF1A-MODY is a monogenic form of diabetes caused by variants in the HNF1A gene. Different HNF1A variants are associated with differences in age of disease onset, but other factors are postulated to influence thi...

    Authors: Agnieszka H. Ludwig-Słomczyńska, Michał T. Seweryn, Piotr Radkowski, Przemysław Kapusta, Julita Machlowska, Stepanka Pruhova, Daniela Gasperikova, Christine Bellanne-Chantelot, Andrew Hattersley, Balamurugan Kandasamy, Lisa Letourneau-Freiberg, Louis Philipson, Alessandro Doria, Paweł P. Wołkow, Maciej T. Małecki and Tomasz Klupa
    Citation: Molecular Medicine 2022 28:113
    Content type: Research article Published on:

  39. Long non-coding RNAs (lncRNAs) have emerged as regulators of human malignancies, including ovarian cancer (OC). LncRNA KCNQ1OT1 could promote OC progression, and EIF2B5 was associated with development of sever...

    Authors: Si-Li He, Ya-Ling Chen, Qi-Hua Chen, Qi Tian and Shui-Jing Yi
    Citation: Molecular Medicine 2022 28:112
    Content type: Research article Published on:

  40. Breast cancer has become the most frequently diagnosed cancer worldwide. Increasing evidence indicated that zinc finger proteins (ZNFs), the largest family of transcription factors, contribute to cancer develo...

    Authors: Qing-Xiang Meng, Ke-Nie Wang, Jun-Hui Li, Hui Zhang, Zhao-Hui Chen, Xue-Jie Zhou, Xu-Chen Cao, Ping Wang and Yue Yu
    Citation: Molecular Medicine 2022 28:111
    Content type: Research article Published on:

  42. Targeting ribosome biogenesis to activate p53 has recently emerged as a therapeutic strategy in human cancer. Among various ribosomal proteins, RPL11 centralizes the nucleolar stress-sensing pathway by binding...

    Authors: Bingwu Wang, Jian Gao, Zhongjun Zhao, Xuefei Zhong, Hao Cui, Hui Hou, Yanping Zhang, Junnian Zheng, Jiehui Di and Yong Liu
    Citation: Molecular Medicine 2022 28:109
    Content type: Research article Published on:

  43. High-mobility group box 1 protein (HMGB1) is an ubiquitous nuclear protein that once released in the extracellular space acts as a Damage Associated Molecular Pattern and promotes inflammation. HMGB1 is signif...

    Authors: Federica De Leo, Alice Rossi, Francesco De Marchis, Cristina Cigana, Medede Melessike, Giacomo Quilici, Ida De Fino, Malisa Vittoria Mantonico, Chantal Fabris, Alessandra Bragonzi, Marco Emilio Bianchi and Giovanna Musco
    Citation: Molecular Medicine 2022 28:108
    Content type: Research article Published on:

  45. Acute pancreatitis is the sudden inflammation of the pancreas. Severe cases of acute pancreatitis are potentially fatal and have no specific treatment available. Premature trypsinogen activation could initiate...

    Authors: Juan Xiao, Wenying Zeng, Pengcheng Zhang, Yuan Zhou and Qiangqiang Fang
    Citation: Molecular Medicine 2022 28:106
    Content type: Research article Published on:

  46. The etiology and most risk factors for a sporadic first primary neoplasm in childhood or subsequent second primary neoplasms are still unknown. One established causal factor for therapy-associated second prima...

    Authors: Caine Lucas Grandt, Lara Kim Brackmann, Alicia Poplawski, Heike Schwarz, Willempje Hummel-Bartenschlager, Thomas Hankeln, Christiane Kraemer, Federico Marini, Sebastian Zahnreich, Iris Schmitt, Philipp Drees, Johanna Mirsch, Desiree Grabow, Heinz Schmidberger, Harald Binder, Moritz Hess…
    Citation: Molecular Medicine 2022 28:105
    Content type: Research article Published on:

  47. Inflammatory bowel disease (IBD) is a common chronic remitting disease with no satisfactory treatment. The aim of this study was to investigate the protective effect of α7 nicotinic acetylcholine receptor (α7n...

    Authors: Wenyuan Pu, Zhenzi Su, Junaid Wazir, Chen Zhao, Lulu Wei, Ranran Wang, Qiyi Chen, Saifang Zheng, Shaoyi Zhang and Hongwei Wang
    Citation: Molecular Medicine 2022 28:104
    Content type: Research article Published on:

  48. Acute kidney injury (AKI) is still a critical problem in clinical practice, with a heavy burden for national health system around the world. It is notable that sepsis is the predominant cause of AKI for patien...

    Authors: Xianzhi Li, Xiaojun Zhou, Xigao Liu, Xiaoyun Li, Xianzhou Jiang, Benkang Shi and Shuo Wang
    Citation: Molecular Medicine 2022 28:103
    Content type: Research article Published on:

  49. It is well-known that both macrophages and osteocytes are critical regulators of osteogenesis and osteoclastogenesis, yet there is limited understanding of the macrophage-osteocyte interaction, and how their c...

    Authors: Shengfang Wang, Lan Xiao, Indira Prasadam, Ross Crawford, Yinghong Zhou and Yin Xiao
    Citation: Molecular Medicine 2022 28:102
    Content type: Research article Published on:

  50. Deregulated translation initiation is implicated extensively in cancer initiation and progression. It is actively pursued as a viable target that circumvents the dependency on oncogenic signaling, a significan...

    Authors: Forum Kayastha, Noah B. Herrington, Bandish Kapadia, Anirban Roychowdhury, Nahid Nanaji, Glen E. Kellogg and Ronald B. Gartenhaus
    Citation: Molecular Medicine 2022 28:101
    Content type: Research article Published on:
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Molecular Medicine

ISSN: 1528-3658